Prof. Dr.Sci, Ph.D, M.D. Tinatin Chikovani


Prof. Dr.Sci, Ph.D, M.D. Tinatin Chikovani
Consultant

Professor of Immunology

PRESENT TITLE

Professor of Medicine, Head of Department of Immunology, Tbilisi State Medical University, Tbilisi, Georgia

Head of Department of Education Management, Assessment and Students Registration, Tbilisi State Medical University, Tbilisi, Georgia

EDUCATION

1974-1980 Diploma cum laude, Faculty of Medicine, Tbilisi State Medical Institute 1980-1982 License in Internal Medicine, Tbilisi State Medical University, Georgia

1989

Diploma, Candidate of Medical Sciences. Title of thesis: "Immunoregulatory action

of peptide fraction received from amniotic membrane and Plaferon”.

1997

Diploma, Doctor of Medical Sciences. Specialty "Allergology and Immunology". Title of thesis

"Immunopharmacology of Plaferon LB".

2009

Certificate, Evidenced Based Medicine: Master Course for Medical Faculty

WORKING EXPERIENCE

2020 – up today Head of Department of Education Management, Assessment and Students Registration, Tbilisi State Medical University

2006 – 2020 Dean of Medical Faculty, Tbilisi State Medical University

2005-2006 Dean of Medical and Biology Faculty, Medical Academy, Tbilisi 2004-2005 Vice-Rector of Tbilisi State Medical University, Tbilisi

2004-2005 Dean of English Medium Medical Faculty, Tbilisi State Medical University,Tbilisi 2003 -2015 Professor of Microbiology@Immunology Department, Tbilisi State Medical University 2015 up today Head of Immunology Department, Tbilisi State Medical University,

1998 - 2003 Georgian-American Medical School "AIETI". Head of Microbiology&Immunology Department 1999 – 2012 Head of Department of Biomedicine. Institute of Medical Biotechnology

1997 - 1999 Leading researcher. Department of Biomedicine. Institute of Medical Biotechnology. 1991 -1997 Senior researcher. Department of Biomedicine. Institute of Medical Biotechnology. 1988 - 1991 Researcher. Institute of Experimental Morphology.

1983 -1988 Post-graduate student of Institute of Experimental Morphology. Speciality "Allergology and Immunology".

1980 -1982 Residency in Tbilisi State Medical University. Speciality "Therapy". 1991 - 2012 Scientific Board Member of Institute of Medical Biotechnology

2001 - up today Member of the Scientific-Certifying Board. Tbilisi State Medical University.

2013-2014 John Snow, Inc - Sustain Program Expert in RH/FP (Rapid Health-Future Project) - delivering the trainings to Medical Faculties

2018-2019 CellMax Life Ltd. Liquid biopsy company. Sunnyvale, CA. CME lecture speaker


PARTICIPATION IN RESEARCH GRANT PROJECTS

 

Years

Position / Responsibility

Project Title

Donor Organization

1

1997-

1999

PI

The influence of Plaferon LB on cytotoxicity effect of glutamate

Georgian Academy of Sciences

2

2000-

2001

PI

Study of placenta peptides in experimental model of hepatitis

Georgian Academy of Sciences

3

2002-

2003

PI

Study of the influence of placenta peptides on extra hepatic organs in immune-mediated

liver injury

Georgian Academy of Sciences

4

2004-

2005

PI

Study of plaferon LB on regeneration of peripheral nerve

Georgian Academy of Sciences

5

1999

Researcher

Prevalence of skin reactions to natural rubber latex in hospital personnel in Russia

and Eastern Europe

I.R.I.N.E

6

2000-

2001

Mentor

Influence of Plaferon LB on production of inducible NO

INTAS Fellowship Grant for young scientist

7

2008-

2009

PI

Cytokines and regulatory T cells in pathogenesis of type 1 diabetes mellitus

Georgian National Science Foundation

8

2008-

2009

Manager

The role of phenotypic and functional changes of regulatory T cells and cytokines

in healthy ageing (Manager)

Georgian National Science Foundation

9

2008-

2009

PI

The protective Role of Edible Plant-Derived Extracts on Age-related Immune Dysfunction

Science and Technology Center, Ukraine (STCU) and Georgian National Science

Foundation (GNSF)

10

2009-

2011

Researcher

Possible Interaction of Endogenous Sodium

Pump Inhibitors and Genetic Factors in the Development of Salt-sensitive Hypertension

Swiss National Foundation - SCOPES

11

2013-

2015

Researcher

Phase I clinical study to determine the safety and efficacy of oligonucleotides to normalise serum albumin and bilirubin and improve liver function in patients with liver

insufficiency

MiNA Therapeutics Limited, UK

12

2014-

2017

Co-Director

The impact of radiofrequency thermal ablation (RFA) on adaptive immune responses in patients with liver cancer (Co-

director)

Shota Rustaveli National Science Foundation

13

2015-

2017

Researcher

The role of immune parameters and circulating tumor cells in colorectal cancer

recurrence and metastasis

Science&Technology Center in Ukraine (STCU)

14

2017-

2019

Supervisor

PhD Fellow’s Project - The effect of radiofrequency ablation on the immune

response of inoperable pancreatic cancer

Shota Rustaveli National Science Foundation

15

2018-

2019

Supervisor

Horizon 2020 PG-2018 New therapies for non-communicated diseases

Shota Rustaveli National Science Foundation

 

COMMUNITY ACTIVITY

1998 - 2008:   Scientific secretary of Georgian Association of Allergology & Clinical Immunology 2001 - present: Member of European Academy of Allergology and Clinical Immunology

2002 - 2006: Head of Governing Board of Young Scientists Development Center 2008 – 2011: President of Georgian Association of Allergology&Clinical Immunology

2011 – present Past President of Georgian Association of Allergology&Clinical Immunology

2013-2014     John Snow, Inc - Sustain Program Expert in RH/FP (Rapid Health-Future Project) - delivering the trainings to Medical Faculties

2016 – 2018 WAO (World Allergy Organization) Education Committee Member

2019 – present IUIS (International Union of Immunological Societies) Executive Committee member 2020 - present WAO (World Allergy Organization) Education Committee Member


EDITORIAL BOARD MEMBERSHIP

2018-2019 – Springer Nature, World Journal of Surgical Oncology, LIDSEN Publishing. OBM Hepatology and Gastroenterology - Reviewer

2016 - Hindawi. BioMed Research International. Special Issue on “Immunotherapeutic Targeting in Aitoimmune Diseases” – Guest Editor

2015 - Hindawi. BioMed Research International. Special issue on “T Lymphocyte Plasticity in Autoimmunity and Cancer” - Guest Editor

2014 – present J.Georgian Medical News

2010 - J."Innovative Medicine and Biology” Canadian International Monthly Reviewed Journal (CIJIMB)


LANGUAGES AND TECHNICAL SKILLS

  • Fluent in Georgian (native speaker), English and Russian languages.
  • Adept in all major software programs and the Internet.


SELECTED PUBLISHED SCIENTIFIC WORKS:

  • Bakhutasvili V, Shakarishvili R, Cheishvili N, Chikovani T. // Plaferon. J. Drugs of the Future, 1999, 24:974- 977.
  • Chikovani T., Nakashidze I.,Pantsulaia I., Cheishvili N., Bakhutashvili V. Dynamics of TNF alpha and NO in blood of patients with traumatic shock // Intern.J.Immunorehabil., 2001, v.3, N 3, 143-144
  • Sharashenidze T., Sanikidze T., Chikovani T., Cheishvili N., Bakhutashvili V. Pro- and antioxidant systems in case of Con A induced hepatitis // Georgian Medical News 2001, N12 (81),108-111
  • Sharashenidze T., Sanikidze T., Chikovani T., Cheishvili N., Bakhutashvili V. Influence of Plaferon LB on liver tissue experimental model of hepatitis // Intern.J.Immunorehabil., 2001, v.3, N 3 145-146
  • Chikovani T., Nakashidze I.,Pantsulaia I., Sanikidze T.,Cheishvili N., Bakhutashvili V. Effect of different methods of therapy on plasma levels of TNF-alpha and NO un traumatic shock // Scandinavian Journal of Immunology, 2001, Vl.54, S 1, 56 A9.Mon.3.11/573
  • Kvezereli M., Chikovani T., Sanikidze T., Rukhadze R., Cheishvili N., Sharashenidze T., Papava M., Bakhutashvili V. Effects of Plaferon LB (PLB) on concanavalin A-induced hepatitis in mice // Tbilisi State Medical University. Annals of Biomedical Research and Education, 2002, April/June, V2, Issue2, 133-138
  • Kvezereli M., Chikovani T., Sanikidze T., Rukhadze R., Cheishvili N., Sharashenidze T., Papava M., Bakhutashvili V. Effects of Plaferon LB (PLB) on concanavalin A-induced hepatitis in mice 6th John Humphrey Advanced Summer Programme in Immunology, Abstracts, Pushchino, 2002, Sep15-22, 67.
  • Sharashenidze T., Cheishvili N., Chikovani T., Rukhadze R.Changes in NO metabolism in case of con A- induced hepatitis // Georgian Medical News, 2002, 6(87) 83-86

    • Sharashenidze T., Cheishvili N., Chikovani T., Rukhadze R.Changes in NO metabolism in case of con A- induced hepatitis // Georgian Medical News, 2002, 6(87) 83-86
  •  
  • Cheishvili N, Sharashenidze T, Chikovani T, Sanikidze T, Rukhadze R., Iobadze, M Jgenti M, Janashia N., Bakhutashvili V. Effect of Plaferon LB on Alterations Developed in Spleen in Case of Concanavalin A Induced Hepatitis.// Bulletin of the Georgian Academy of Sciences 2003 v.168,N 2,352-355
    • Chikovani T., Sanikidze T., Kikodze N., Nanava G., Bakhutashvili V. Antioxidant Effect of Immunotropic Drug Plaferon LB in Early Post-operative Period in Patients with Brain Tumor // Intern.J.Immunorehabil., 2004, v.6, N , 217-223
    • Cheishvili N., Chikovani T., Rukhadze R., Sanikidze T., Kulikova N., Iobadze M., Jgenti M Early treatment of experimental hepatitis by Plaferon LB // Bulletin of the Georgian Academy of Sciences 2004,v.169, N 3,615- 618
    • Khapava I., Rukhadze R., Chikovani T., Iobadze M., Cheishvili N., Chochua S., Kukuladze N., Jgenti M.Morpho-functional changes of spleen in case of traumatic shock and their correction with plaferon LB // Proc.Georgian Acad. Sci. Biol.Ser.A, 2004, N2, V. 30, 285-290.
    • Kvezereli M., Giorgadze T., Gorgadze V., Gongadze M., Kikodze N., Chikovani T. Influence of Plaferon LB on Nitric oxide production in process of sciatic nerve regeneration // Proc.Georgian Acad.Sci. Biol. Ser. A 2004, V.30, N6, 815-820
    • Giorgadze T., Kvezereli M., Chikovani T., Gorgadze V., Burkadze G., Influence of Plaferon LB on Nitric Oxide (NO) production in process of sciatic nerve regeneration, Georgian Medical News,No 12(117), 2004
    • Giorgadze T., Kvezereli M., Chikovani T., Gorgadze V., Burkadze G. Effect of Plaferon LB on the Injured Sciatic Nerve Regeneration TSMU, Annals of Biomedical Research and Education, 4 (2), 76-80, 2004
    • Chikovani T., Kvezereli M., Burkadze G., Giorgadze T., Bakhutashvili V. Effect of plaferon LB on damaged peripheral nerve regeneration. Clinical Immunology 115: S75-S76 Suppl. 1, 2005.
    • Kikodze N., Iobadze M., Chikovani T., Sirbiladze G., Kukuladze N., Jgenti M. Protective effect of Plaferon LB on liver in cases of some pathologies // Proc.Georgian Acad. Sci. Biol.Ser.A, 2006, N2, V. 32, 325-329
    • Chochua S., Kikodze N., Iobadze M., Pantsulaia I., Sujashvili L., Chikovani T. Sirbiladze G. Caspase-3 and caspase-8 activities in experimental endotoxemia and their regulation by immunomodulatory drugs
  • //Experimental and Clinical Medicine 2006 , N4, 85-87

    • Sirbiladze G., Kikodze N., Iobadze M., Jgenti M., Pantsulaia I., Chikovani T. Activities of caspases in experimental mild hepatitis and their regulation by immunomodulators // Bulletin of the GeorgianAcademy of Sciences 2006, v.173, N 2, 140-143
    • Sirbiladze G., Kikodze N., Iobadze M., Chikovani T. Modulation of NO synthesis by Plaferon LB in liver // Georgian Medical News 2006, Apr.,(133):102-104
    • Sirbiladze G., Chochua S., Iobadze M., Pantsulaia I., Kikodze N., Chikovani T. Regulation Activities of Caspases in Experimental Liver Injury by Immunomodulatory Drugs Alergologia i immunologia, 7(5), 2006, 616-618
    • G.Sirbiladze, N.Kikodze, M.Iobadze, M.Kvezereli, I.Pantsulaia, T.Chikovani Prevention of Immunity- mediated Liver Injury by Plaferon LB. Proc.Georgian Acad.Sci., Biol. Ser. A, 2006, vol.32 Suppl., S381-S384.
    • M.Kvezereli, I.Pantsulaia, N.Kikodze, M.Iobadze T.Chikovani Maturation of Bone Marrow-Derived Dendritic Cells Enhanced by Plaferon-LB Experimental &Clinical Medicine, N4 (37) 2007, 23-25.
    • I.Pantsulaia, A. Sepashvili, T.Chikovani Treg cells in the Pathogenesis of Asthma. Georgian Respiratory Journal., 2009, 5(1), 48-52.
    • Pantsulaia N., Kikodze. N, Iobadze M., Sepashvili A, Pantsulaia. I., Chikovani T. Plasma pro- and anti- inflammatory cytokine profiles in apparently healthy aged Georgian population. Explerimentuli da clinikuri medicina, 2009, 7(52), 13-18
    • Pantsulaia N., Kikodze. N, Iobadze M., Rekhviashvili Kh, Lasareishvili B., Pantsulaia. I., Chikovani T Age- related changes of T reg cells in Georgian Healthy population Explerimentuli da clinikuri medicina, 2009, 3(47) 78-81.

      • I.Pantsulaia, A.Sepashvili, M.Iobadze, I.Chkhikvishvili, N.Kikodze, T.Chikovani The Effect of Citrus Extract on the Immune-mediared Liver Injury: Involvement of Regulatory T Cells. Intern. J. Immunoreh., 2009, V.11 No 2. p.202
      • I.Pantsulaia, N.Kikodze, M.Iobadze,N.Pantsulaia, Kh.Rekhviashvili, B.Lasareishvili, N.Jakhutashvili, T.Chikovani Aging and Immunoregulatory T Cells in Georgian Population Intern. J. Immunoreh., 2009, V.11 No 2. p.20
      • Nakashidze IM, Chikovani TI, Tsitsadze NG, Datunashvili IV, Sanikidze TV. Influence of antioxidants under polytrauma during traumatic sickness Georgian Med News. 2009 Jun;(171):72-5.
      • Nakashidze IM, Chikovani TI, Sanikidze TV, Tsintsadze NG.The condition of oxidation-antioxidation balance of kidney andsuprarenal tissue in experimental traumatic shock with white rats and the influence of Plaferon LB.Georgian Med News. 2009 Jun;(171):68-72.
      • Pantsulaia I., Iobadze M., Putkaradze J., Lasareishvili B., Pantsulaia N., Kikodze, Chikovani T. Effect of edible plant-derived extract on pro- and anti-inflammatory cytokines’ levels in healthy elderly individuals. International Journal on Immunorehabilation V. 12, N1. 31-34, 2010
      • Chikovani T., Kikodze N., Iobadze M., Pantsulaia N., Rekhviashvili Kh. Pantsulaia CD4+CD25+ T cells and cytokines levels in patients with different stages of type I diabetes mellitus. Diabetes (PP-104) International Immunology Meeting Abstracts (2010) 22 (Suppl 1 Pt 1): i156-i164. doi: 10.1093/intimm/dxq138; Day 1: 14th International Congress of Immunology Kobe, Japan http://intimmabs.oxfordjournals.org/content/22/Suppl_1_Pt_1/i156.citation
      • Pantsulaia I., Kikodze N., Iobadze M, Pantsulaia N., Lasareishvili B., Chikovani T. Plasma pro- and anti- inflammatory cytokine profiles in apparently healthy aged Georgian population Aging and immunity (PP-105) International Immunology Meeting Abstracts (2010) 22 (Suppl 1 Pt 4): iv148-iv152. Day 4: 14th International Congress of Immunology Kobe, Japan 2010; http://intimmabs.oxfordjournals.org/content/22/Suppl_1_Pt_4/iv148.citation
      • Sepashvili A., Iobadze M., Chkhikvishvili I., Pantsulaia N., Chikovani T., Kikodze N. Pantsulaia I. Immunomodulatory activity of Citrus Peel Extract 39th meeting of Scandinavian Society for Immunology jointly with the Baltic Immunological Society June 2-5, 2010, Tallinn, Estonia Scandinavian Journal of Immunology, Volume 71, Issue 6, pages 474–548
      • Xi Feng, Madhava Pai, Malkhaz Mizandari, Tinatin Chikovani, Duncan Spalding, Long Jao, Nagy Habib Towards the optimisation of management of hepatocellular carcinoma Front. Med. 2011, 5(3): 271–276. DOI 10.1007/s11684-011-0148-4
      • Pantsulaia I., Topuria T., Kharischarishvili I., Chikovani T. Hair micro and macro elements status in patients with cystic fibrosis. J.Innovative Medicine and Biology, 2011, N4-5, p.20-29.
      • Rekhviashvili Kh., Iobadze M., Pantsulaia N., Kikodze N., Bikashvili N., Metreveli D., Pantsulaia I., Chikovani T. Cytokines (IL-6, IL-10, TNF-alpha, INF-gamma) in Pathogenesis of Type 1 Diabetes Mellitus. Collection of Scientific Works. Tbilisi State Medical University, XLVI, 77-80, 2012
      • Kh Rekhviashvili, I.Pantsulaia , N.Jakhutashvili, M.Iobadze, N.Pantsulaia, N.Kikodze, N.Bikashvili, D.Metreveli, Chikovani T. CD4+CD25+ T regulatory cells in pathogeneses of diabetes type I Experimental and Clinical Medicine 2013 (2)11-15.
      • Lasareishvili B., Pantsulaia N., Iobadze M., Kikodze N., Pantsulaia I., Chikovani T. The influence of age, sex and anthropomorphic parameters on subsets of lymphocytes in Georgia’s population. Collection of Scientific Works, Tbilisi State Medical University, 2013, XLVII, 103-107.
      • Paolo Fagone, Francesco Patti, Katia Mangano1, Santa Mammana, Marinella Coco1, Chafia Touil-Boukoffa, Tinatin Chikovani, Roberto Di Marco, Ferdinando Nicoletti Heme Oxygenase-1 expression in peripheral blood mononuclear cells correlates with disease activity in Multiple Sclerosis J. Neuroimmunol. (2013), http://dx.doi.org/10.1016/j.jneuroim.2013.04.013
      • Kikodze N., Pantsulaia I., Rekhviashvili Kh., Iobadze M., Jakhutashvili N.,Pantsulaia N., Bikashvili N., Metreveli D., Chikovani T. Cytokines and T regulatory cells in the pathogenesis of Type 1 Diabetes Georgian Medical News, 2013, No9 (222):29-35

        • Reebye V, Saetrom P, Mintz PJ, Huang KW, Swiderski P, Peng L, Liu C, Liu XX, Jensen S, Zacharoulis D, Kostomitsopoulos N, Kasahara N, Nicholls JP, Jiao LR, Pai M, Mizandari M, Chikovani T, Emara MM, Haoudi A, Tomalia DA, Rossi JJ, Habib NA, Spalding DR. A novel RNA oligonucleotide improves liver function and inhibits liver carcinogenesis in vivo. Hepatology. 2014 Jan;59(1):216-27. doi: 10.1002/hep.26669. Epub 2013 Dec 9.
        • Lasareishvili B., Pantsulaia I., Chikovani T. Aging and Immune System Experimental and Clinical Medicine 2014 (2)66-80.
        • Chikovani T., Pantsulaia I.,Kikodze N., Iobadze M., Pantsulaia N., Lasareishvili B. Immunosenescence: A study in Healthy Elderly Population Allergy, Asthma& Immunopathology: From Gene to Clinical Management (New-York, April 26-29), Medimond. International Proceeding, 2014, p.73-78
        • Pantsulaia I., Sepashvili A., Iobadze M., Pantsulaia N., Kikodze N., Chikovani T. Profiles of serum cytokines and Tregs in acute liver failure Allergy, Asthma & Immunopathology: From Gene to Clinical Management (New-York, April 26-29), Medimond. International Proceeding, 2014, p.78-83
        • Ia Pantsulaia, Manana Iobadze, Nato Pantsulaia and Tinatin Chikovani The effect of citrus peel extracts on cytokines levels and T regulatory cells in acute liver injury BioMed Research International, vol. 2014, Article ID 127879, 7 pages, 2014. doi:10.1155/2014/127879.
        • B.Lasareishvili, I.Pantsulaia, M.Iobadze,N.Kukuladze,N.Kikodze, T.Chikovani. Relationship between blood lipid fractions and T cells populations in healthy elderly population International J. Immunorehab, 2014 V16(2), 121
        • Lasareishvili B., Pantsulaia I., Iobadze M., Kukuladze N., Kikodze N., Chikovani T. Correlations between the lipid profile and the immunological characteristics in the elderly Georgian Medical News No 6 (243) 2015, p.52- 58
        • Pantsulaia I., Iobadze M., Kikodze N., Pantsulaia N., Chikovani T. Lipid profile and cytokines interactions during successful aging. Georgian Medical News No 6 (243) 2015, p.46-51
        • Magen E., Chikovani T. Case report of irritable bowel syndrome responding to Omalizumab. Georgian Medical News No 6 (243) 2015, p.42-45.
        • N.Kikodze, M.Iobadze, I.Pantsulaia, K.Mazmishvili, M.Mizandari, T.Chikovani, N.Janikashvili Ectonucleotidase CD39 expression on circulating CD4+ T lymphocytes of patients with liver cancer Intern. J. Immunoreh., 2015, vol.17, N1 p.29
        • Mazmishvili K., Kikodze N., Iobadze M., Rekhviashvili Kh., Nanava N., Pantsulaia I., Mizandari M., Janikashvili N., Chikovani T. Hepatocellular carcinoma: current and prospective immunotherapeutic strategies. Georgian Medical News. No 9 (246) 2015,78-84
        • Ia Pantsulaia, Archil Aladashvili, Nino Kikodze, Manana Iobadze, Nona Janikashvili, Keteven Mazmishvili, Tsitsino Atamashvili, Tinatin Chikovani CD4 T Cell Subpopulations in Colorectal and Liver Cancer Patients, Tumor Biology, 2015,V.36 (Suppl): S43
        • T.Chikovani, N. Kikodze, K.Mazmishvili, N.Paksashvili, I. Pantsulaia, M.Iobadze, M.Mizandari, N.Janikashvili The impact of Radiofrequecy Thermal Ablation on Immune Response in Patients with Liver Cancer Intern J.Immunoreh., 2015, V.17(2), p.78-79.
        • Paolo Fagone, Katia Mangano, Roberto Di Marco, Chafia Touil-Boukoffa, Tinatin Chikovani, Santo Signorelli, Giuseppe A.G. Lombardo, Francesco Patti, Santa Mammana, Ferdinando Nicoletti Expression of DNA methylation genes in secondary progressive multiple sclerosis Journal of Neuroimmunology 290 (2016) 66–69
        • Malkhaz Mizandari, Tamta Azrumelashvili, Natela Paksashvili, Nino Kikodze,Ia Pantsulaia, Nona Janikashvili, and Tinatin Chikovani. Tumor Regression in HCC Patient with Portal Vein Tumor Thrombosis after Intraportal Radiofrequency Thermal Ablation, Case Reports in Hepatology, vol. 2016, Article ID 6843121, 6 pages, 2016. doi:10.1155/2016/6843121
        • Nona Janikashvili, Maxime Samson, Eli Magen, and Tinatin Chikovani. Editorial: Immunotherapeutic Targeting in Autoimmune Diseases. Mediators ofInflammation. Volume 2016. Article ID 1432702
      •  
        • Eli Magen, Tinatin Chikovani Possible therapeutic role of IgE blockade in irritable bowel syndrome World J Gastroenterol 2016 November 21; 22(43): 9451-9456
        • Kikodze N., Pantsulaia I., Chikovani T. The role of T regulatory and T17 cells in the pathogenesis of rheumatoid arthritis (Review). Georgian Medical News, No12 (261) 2016, p.62-68.
        • Mizandari M, Paksashvili N, Kikodze N, Azrumelashvili T, Pantsulaia I, Shanava K, Janikashvili N, Chikovani T. Long-term survival in a patient with low level inflammatory markers and liver metastasis, converted resectable by TACE. Immunotherapy. 2017 Oct;9(13):1067-1069. doi: 10.2217/imt-2017-0069.
        • M.Jgharkava, I.Pantsulaia, T.Chikovani, K.Chelidze. Cellular senescence, vascular aging, gut microbiota and atherosclerosis. Experimental&Clinical Medicine,2017(5):35-39.
        • K.Mazmishvili, N.Kikodze, I.Pantsulaia, M.Iobadze, N.Janikashvili, T.Chikovani. Altered neutrophil/lymphocyte and platelet/lymphocyte ratios in the peripheral blood of patients with liver cancer. Experimental&Clinical Medicine, 2018(2):147-152.
        • M.Mizandari, J.Kumar, M.Pai, T.Chikovani, T.Azrumelashvili, I.Reccia, N.Habib. Interventional radiofrequency ablation: A promising therapeutic modality in the management of malignant biliary and pancreatic duct obstruction Journal of Cancer 2018; 9(4): 629-637. doi: 10.7150/jca.23280
        • E.Magen,T.Chikovani, Dan-Andrei Waitman, N.R.Kahan. Association of alopecia areata with atopic dermatitis and chronic spontaneous urticaria. Allergy and Asthma Proceedings 2018; 39(2):96-102. doi: 10.2500/aap.2018.39.4114
        • E.Magen, T.Chikovani. A case of food-dependent exercise-induced angioedema.The Journal of Allergy and Clinical Immunology: In Practice doi.org/10.1016/j.jaip.2018.05.017
        • E.Magen, T.Chikovani. Development of angio‐oedema after omalizumab injections in a patient with chronic spontaneous urticaria Clinical and experimental dermatology, 2018 doi.org/10.1111/ced.13616
        • P.Fagone, E.Mazzon, T.Chikovani, A.Saraceno, S.Mammana, G.Colletti, K.Mangano, P.Bramanti, F.Nicoletti. Decitabine induces regulatory T cells, inhibits the production of IFN-gamma and IL-17 and exerts preventive and therapeutic efficacy in rodent experimental autoimmune neuritis. Journal of Neuroimmunology 321 (2018) 41– 48 www.elsevier.com/locate/jneuroim
        • K.Mazmishvili, K.Jayant, N.Janikashvili, N.Kikodze, M.Mizandari, I.Pantsulaia, N.Paksashvili, M. Sodergren, I.Reccia, N.Habib, T.Chikovani. Study to assess the impact of radiofrequency ablation (RFA) on immune system in comparison to liver resection in hepatic cancer Journal of Cancer 2018; 9(17): 3187-3195. doi: 10.7150/jca.25084
        • N. Janikashvili, K. Jayant, N. Kikodze, K. Mazmishvili, I. Pantsulaia, B. Sandhu, M. Podda, M. Iobadze, T. Azrumelashvili, M. Mizandari, N. Habib and T. Chikovani. Immunomodulatory changes following isolated RF ablation in colorectal liver metastases: a case report Medicines 2019, Volume 6, Issue 2, 56
        • Eli Magen, Tinatin Chikovani. A case of food-dependent exercise-induced angioedema The Journal of Allergy and Clinical Immunology: In Practice 2019, 7 (1), 312-313
        • E Magen, T Chikovani, DA Waitman, NR Kahan Factors related to omalizumab resistance in chronic spontaneous urticaria. Allergy & Asthma Proceedings Jul2019, 40 (4) p273-278
        • N Janikashvili, N Kikodze, M Iobadze, K Mazmishvili, N Paksashvili, I Pantsulaia, A Gvajaia, M Mizandari, T Chikovani The Differential Effects of Radiofrequency Ablation and Hepatic Resection on Serum IL-10 Level in Patients with Liver Cancer Journal of Cancer Science and Clinical Therapeutics, 2019, 3, 137-142
        • N Toria, N Kikodze, R Rukhadze, M Mizandari, T Chikovani Inflammatory Biomarkers in Patients with Unresectable pancreatic Cancer: A Retrospective Study. Georgian medical news, 2020 Feb;(299):21-26.
        • E Magen, T Chikovani Recurrent spontaneous clearance of psoriasis during exacerbations of concomitant chronic spontaneous urticaria Clinical Case Reports 2020;00:1–3. doi.org/10.1002/ccr3.2930
        • M.Mizandari, T.Azrumelashvili, N.Toria, N.Nanava, I.Pantsulaia, N.Kikodze, N. Janikashvili, T.Chikovani Cured giant hepatocellular carcinoma after transarterial embolization complicated with liver abscess formation Radiadiology Case Reports 15 (2020) 1485-1492

        • PARTICIPATION IN VARIOUS SCIENTIFIC FORUMS:

          1995 - Annual II International Congress on Rehabilitation 6-9 July, Dagomys, Russia. 1998 – International Falk Symposium, Tbilisi, Georgia;

          1999 - V International Congress on Immunorehabilitation, 2-5 May, Tenerife, Spain;

          1999 - I International Congress in “Modern Methods of Diagnostic and Treatment Asthma, Allergy and clinical

          Immunology” 21-25 September, Tbilisi, Georgia;

          2000 – VI International Congress on Immunorehabilitation, 3-6 May, Eilat, Israel;

          2001 - II International Congress in “Modern Methods of Diagnostic and Treatment Asthma, Allergy and clinical Immunology”, June, Tbilisi, Georgia;

          2001 – European Asthma Congress 9-14 September, Moscow, Russia;

          2001 - VII International Congress on Immunorehabilitation, 14-17 April, New York, USA; 2002 – VIII International Congress on Immunorehabilitation, 21-24 September, Cane, France; 2002 – World Congress on Immunopathology, 2-6 December, Singapore;

          2003 – III Meeting of Federation Clinical Immunology Associations, 15-19 May, Paris, France; 2003 – VII World Asthma Congress 5-8 July, St Petersburg, Russia;

          2004 - II European Asthma Congress, I International Congress “Health & Drugs”, September, Tbilisi, Georgia.

          2005 - III European Asthma Congress, Athens, Greece

          2006 - III International. Congress "Modern Problems in Allergology, Immunology&Medical Biotechnology", II

          International Congress “Health & Drugs”, 25-28 September, Tbilisi, Georgia.

          2007 - The 1st International Congress. Georgian Respiratory Association. Scientific Committee Chair

          2008 - IV International. Congress "Modern Problems in Allergology, Immunology&Medical Biotechnology" Congress Co-chairperson, Speaker, Chairperson - Symposium "Epitop-Specific Vaccines", 26-28 September

          2009 - October 17-20, Tel-Aviv, Israel. V Congress on Immunopathology&Respiratory Allergy, Speaker, Chairperson

          2010 – VI International Conference “New Perspectives of Health Care in South Caucasus Region”, March 25-28, Tbilisi, Georgia

          2010 – III World Asthma&COPD Forum, April 24-27, Dubai, UAE. Faculty member

          2010 – Georgian Respiratory Association 2nd International Congress, June 10-12, Batumi, Georgia Programme Committee member

          2010 – 25th IUSTI Europe Conference, September 23-25, Tbilisi, Georgia, Participant

          2010 – VI Georgian Congress of Allergology and Immunology, IV International Congress “Health and Drug”,

          Tbilisi-Tskhaltibo, Georgia, October 1-3, 2010. Congress Co-chairperson, Speaker, Chairperson 2011 – 2nd South Caucasian Conference on Rare Diseases and Orphan Drugs, October 27-28, Tbilisi,

          Georgia

          2012 - V World Asthma&COPD Forum, April 21-24. Plenary Session's Chairman, Poster Session's Moderator, New York, USA

          2012 – First International Symposium “Stem Cells&Regenerative Medicine”, Tbilisi, June 23

          2012 – VII Georgian Congress of Allergology and Immunology, V International Congress “Health and Drug”, October 5-8, Tskaltubo – Batumi, Georgia, Co-chairman of program committee, Speaker, Chairperson

          2013 – Third National Congress of Georgian I.Beritashvili Society of Physiologistd (GBSPh), September, 26-28, Tbilisi, Georgia

          2013 – VIII World Congress on Immunopathology, Respiratory Allergy&Asthma and the XIX International Congress on Rehabilitation in Medicine & Immunorehabilitation, October 12-15, Dubai, UAE

          2014 – VII World Asthma, Allergy & COPD Forum. XX World Congress on Rehabilitation in Medicine & Immunorehabilitation, April 26-29, New York, USA

          2014 - IV International Congress of the Georgian Respiratory Association, June 19-21, Chairman, Speaker, Batumi, Georgia

           

          2014 – 6th International Conference “Health and Ecology”, July 26-28, Mestia, Georgia

          2015 – VIII World Asthma, Allergy&COPD Forum, April 26-29, Chairman, Speaker, Singapore

          2015 – VIII Georgian Congress of Allergy, Asthma&Immunology. Tbilisi-Tskaltubo, June 24-27, Co-Chairman of congress program committee

          2015 – 7th International Conference “Health and Ecology”, Sairme, Georgia, October 16-18

          2016 – X World Congress on Asthma, COPD and Immunopathology, Dubai, Ferbuary 6-9, Moderator of Keynote Lecture, Chairman, Speaker

          2016 – 5th International Congress of the Georgian Respiratory Association, Batumi, Georgia, June 23-25 2016 – The First International Anesthesiology and Intensive Care Conference Geoanesthesia 2016, Batumi,

          September 15- 17, Speaker, Chairman

          2016 – 2nd International Transcaucasus congress on photodermatology and skin cancer, October 27-29, Tbilisi, Georgia, Speaker, Chair, Scientific Committee member

          2016 – WAO International Scientific Conference (WISC) 2016, December 6-9, Jerusalem, Israel, attended Education Committee meeting

          2017 - X World Asthma, Allergy and COPD Congress. XXIII World Congress on Clinical Medicine and Immunorehabilitation, New York, USA, April 28 – May 1, Lecture, Chairman, Speaker, Moderator of Poster Session

          2017 – The Second International Anesthesiology and Intensive Care Conference Geoanesthesia 2017, Batumi, September 15- 17, Speaker

          2017 - International Scientific Conference “Future Technologies and quality of life”, 29 September - 1 October 2017, Batumi, Organizing Committee member, Speaker

          2018 – XII World Congress on COPD, Asthma&Respiratory Allergy, 2-5 February, Dubai, UAE, Speaker, Chairman of Plenary session, Moderator of Poster Session

          2018 – VI Europian Congress on Asthma, COPD&Respiratory Allergy. X Georgian National Congress on Allergy, Asthma&Immunology, June 15-19, Tbilisi, Georgia. Co-chairman of Congress

          2018 – The Third International Anesthesiology and Intensive Care Conference Geoanesthesia 2018, Batumi, September 21-23, Speaker, Organizing committee member

          2018 - 5th European Congress of Immunology. September 2-5, Amsterdam. The Netherlands, Speaker 2018 – XII World Congress on COPD, Asthma&Respiratory Allergy, 2-5 February, Dubai, UAE, Speaker,

          Chairman of Plenary session, Moderator of Poster Session

          2019 - Sixth International Conference Cancer Immunotherapy and Immunomonitoring, April 29 – May 2, Tbilisi Georgia, Speaker, Chair of Local Organizing Committee

          2019 - The Fourth International Anesthesiology and Intensive Care Conference Geoanesthesia 2019, Batumi, September 27-29, Speaker, Organizing committee member

          2019 - International Conference “Innovative Approaches in Laboratory Medicine”, October 12, 2019. Speaker


          AREA OF EXPERTISE

          SCIENCE

          Immunology and immunopharmacology, with a particular emphasis on the study of physiologically active substances received from human placenta. Intensive experience in the study of immune regulation in ageing and immune-mediated diseases as well as investigation of different kind of interventional therapy on immune system in experimental and clinical trails

          Under her leadership was awarded 18 PhD degrees


          EDUCATION

          2003 - Warsaw, Poland. Participation in Quality Culture project (A SOCRATES-Sponsored project of EUA).

           

          2003 - Independent Expert, British Council Georgia Project: “State of Affairs within Exact and Natural Sciences in Georgia”

          2006 - June 17 -19, TSMU, Tbilisi, Workshop "Curriculum Development, WFME Standards and Evaluation" 2006 - June 22-23, Napier University, Edinburgh, Scotland, United Kingdom. Bologna Promoters’ Training

          Seminar on the Three-Cycle System

          2006 - December 11-14, Tbilisi, Georgia. National Meeting and ECTS Training Course with the WHO/WFME strategic partnership experts

          2007 - 30 June-1 July, Tbilisi, Italian-Georgian Workshop-Meeting Medical Education and Research: No Border 2007 - 5-6 December, Tbilisi, Symposium "The Technical Enablers and Challenges of Biological Terrorism" 2007 - 17 December, Tbilisi, Postgraduate Medical Education and Continuous Professional Development in

          Europe - Harmonization and Perspectives

          2008 - October 18-25, College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, Scotland, United Kingdom Development of an Integrated Curriculum and Teaching Geriatrics

          2008 - July 25-26, Black Sea Echocardiography School of Professor Erbel

          2009 – May 13-23 Cleveland, Ohio. The Council of International Programs USA & Open World's Medical Education Program (Sponsored by the Open World Leadership Center)

          2009 – June 8-12, Kobuleti, Georgia. Evidenced Based Medicine: Master Course for Medical Faculty (Sponsored by USAID)

          2009 - August 15-26, Baltimore, Washington, USA. Reproductive Healt and Development: Analytical Skills for Medical School Faculty (sponsored by JSI and USAID)

          2010 – March 15-18, Tbilisi, Georgia. Case-Based Teaching Methodology: provided by USAID SUSTAIN in collaboration with Harvard School of Public Health

          2010 – August 10 – 12, BD Biosciences Heidelberg, Germany. Operator Training on BD FACSArray 2010 – October 22, Tbilisi “Modern Trends in Medical Education”

          2011 – April 11-12, Tbilisi “Georgian-Israel Symposium on Emergency Medicine”

          2011 – September 15-17 – Advanced Case-Based Teaching and Assessment: provided by USAID SUSTAIN in collaboration with Harvard School of Public Health, Kobuleti, Georgia

          2011 –20/09-21/09 Assessment for Medical Education. Modified OSCE: provided by WHO/EURO in collaboration with USAID SUSTAIN project, Tbilisi, Georgia

          2012 - 16/02-21/02 – New Objective Structured Clinical Examination (OSCE) of medical students, Oslo University Faculty of Medicine, Oslo, Norway

          2012- 01-01/02 – Opening Conference of Tempus Project “Modernizing Undergraduate Medical Education in EU Eastern Neighboring Area (MUMEENA)”, Tbilisi, Georgia

          2012 - 10/05-11/05 – "Peer Review and Sustainable Science for Georgia" Workshop on Strategies for Success in Proposal Writing, CRDF GLOBAL, Tbilisi Georgia

          2012 - 04/06-06/06 - Conference “Curriculum development. Research skills”. Tempus Project

          “Modernizing Undergraduate Medical Education in EU Eastern Neighboring Area (MUMEENA)”,

          Granada, Spain

          2012 - 10/09-12/09 – OMI Satellite Symposium on Medical Education: provided by The Open Medical Institute, The Children’s Hospital of Philadelphia & Tbilisi State Medical University, Tbilisi, Georgia

          2012 - 10/12-11/12 – Symposium “Main Strategies of Medical Education in 21st Century”: Tempus Project “Modernizing Undergraduate Medical Education in EU Eastern Neighboring Area (MUMEENA)”, Tbilisi, Georgia

          2013 -6/04-8/04 - Theoretical training course for case-based teaching methodology for faculty of Batumi University provided by JSI SUSTAIN in collaboration with Tbilisi State Medical University, Batumi, Georgia. Trainer.

          2013 - 2/07-4.07 – International Workshop on Antimicrobial Resistance. Provided by NCDC, DTRA and TSMU, Tbilisi, Georgia

           

          2013 - 29/08-30/08 - ICH Good Clinical Practice training course Provided by Pharm-Olam, Tbilisi, High technology Medical Center, University Clinic, Tbilisi, Georgia

          2013 - 05/09-06/09 - "Peer Review and Sustainable Science for Georgia" Workshop on Strategies for Success in Proposal Writing, CRDF GLOBAL, Tbilisi, Georgia

          2013 - 19/09 – OSCE: Design, Quality and Future Developments, Tempus Project “Modernizing Undergraduate Medical Education in EU Eastern Neighboring Area (MUMEENA)”, Tbilisi, Georgia

          2014 - 01/07-02/07 - Celebrating Achievements and Looking to the Future of Medical Education in Eastern

          Europe. Tempus Project “Modernizing Undergraduate Medical Education in EU Eastern Neighboring Area

          (MUMEENA)”, Tbilisi, Georgia

          2017 – 27/11-13/12 – “Modern Management’’ provided by Management Academy, Tbilisi, Georgia. Certificate N

          4910.

          2018 – 21/03-22/03 - Workshop for Programme Committee members from Associated EaP countries, Kiev, Ukraine.

          2019- 2019 European Quality Assurance Forum, 21-23 November, Berlin, Germany

          2019 – Essential Skills in Medical Edication, AMEE (Association of Medical Education in Europe) May, 2019, Tbilisi

          2019 – Essential Skills in Medical Edication Assessment, AMEE (Association of Medical Education in Europe) 21-25 October, 2019, Tbilisi



          AWARDS:

          1997-1998 - Presidential Fellowship (First Degree)

          1997 - Travel Award of Open Society Georgia Foundation 1998 - Falk Symposium Diploma

          2001 - First Degree Diploma, II International Congress in “Modern Methods of Diagnostic and Treatment Asthma, Allergy and clinical Immunology”

          2001 - Travel Award of Federation of Clinical Immunology Societies (FOCIS) 2009 – TSMU Students Award for Most Productive Lectures

          2014 – Travel Award of Shota Rustaveli Scientific Foundation

          2016 - Travel Award of World Immunopathology Organization (WIPO) 2017 – SRNSFG Award for the Best Group of Scientists of the year