Professor MD. PhD. Zaza Avaliani


Professor MD. PhD. Zaza Avaliani
Consultant

Professor for Pulmonology

   

BIOGRAPHICAL SKETCH

Provide the following information for the Senior/key personnel and other significant contributors.
Follow this format for each person.  DO NOT EXCEED FOUR PAGES.


NAME

Avaliani Zaza, MD, PhD, Professor

POSITION TITLE

Director

National Center for TB and Lung Disease

eRACOMMONS USER NAME (credential, e.g., agency login)


EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.)

INSTITUTION AND LOCATION

DEGREE

(if applicable)

MM/YY

FIELD OF STUDY

1978-1984

Tbilisi State Medical Institute

MD

Internal medicine

1984-1986

Tbilisi State Medical Institute

Dr.

Pathological  anatomy

1998-2003

Tbilisi State Medical Institute

PhD

Pathological  anatomy






 

A. Personal Statement 

 

My major academic interests are focused on tuberculosis (TB), specifically in the areas of drug resistant. I have been appointed as a director at the National Center for Tuberculosis and Lung Diseases (NCLTD) in Tbilisi, Georgia over 5 years. In my capacity I have supported development of scientific research unit in 2014 at NCTLD. Currently center conducts over 40 scientific research projects, including multicenter phase three clinical trials.  We collaborate with European and US research institutions and foundations such as: Swiss Tropical and Public Health institute, Emory University, Foundation Mareux, MSF, The Union, TB Alliance among many others.

 

B.  Positions and Employment

 

Research Positions:

 

2018-present

Full Professor

European University

2009-2012

Project coordinator

Disability Status Assessment project, Swiss National Fund

2007-2009

Full professor, program leader

IB Euro Caucasian University




2003-2006

Vice-rector / Head of Education/Sciences Department

Education/Sciences Department

Tbilisi State Medical Institute

1998-2007

Associated Professor

Pathology Department, Tbilisi State Medical Institute

1998-2003

Assistant, Dr.

Department of Pathology and Anatomy

Tbilisi State Medical Institute

 

Other Professional Activities





2014-present

Director

National Center for Tuberculosis and Lung Diseases


2013-2014

Medical Director

Abeloff Laboratory, Cancer Research Center




Role: Co-Investogator

DRTB-HDT                                                                                                                            Tukvadze (PI)                                                             01/01/2020-01/01/2025

Horizon 2020, European Commission

Title:Stratified host-directed therapy for rifampicin-resistant TB: a randomized controlled multi-centre trial

The goal of this project will be to determine the efficacy, safety, and tolerability of two adjunctive host-directed therapies (HDTs) in patients with rifampicin-resistant (RIF-R) pulmonary tuberculosis in a multicenter international trial. The selected HDT candidates represent two complementary HDT strategies: reducing inflammation (CC-11050) vs inducing host cell anti-microbial activity (metformin).

Role: Co-Investigator

SMA TB                                                                                                                                              Vashakidze (PI)                                                      01/01/2020-01/01/2025

Horizon 2020, the European Commission

Title: A novel Stratified Medicine Algorithm to predict treatment responses to host-directed therapy (HDT) in TB patients.

The goal of this project is toevaluate in a clinical trial the potential impact of aspirin (an anti-inflammatory HDT) as adjunct to standard therapy for drug sensitive (DS-) and MDR-TB.

Role: Co-Investigator

NCT03086486                                                                                                                        Mikiashvili (PI)                                                             11/21/2017-12/31/2021

Global Alliance for TB Drug Development

Title:ZeNix Trial

The goal of this project is toevaluate the efficacy, safety and tolerability of various doses and durations of linezolid plus bedaquiline and pretomanid after 26 weeks of treatment in participants with either pulmonary XDR-TB, pre-XDR-TB, or treatment intolerant or non-responsive MDR-TB

Role: Co-Investigator


                                               

Completed Research:

 

International Science and Technology Center (ISTC)                                                                     2016-2018

Pharmacokinetics of second-line anti-tuberculosis drugs among patients with multidrug-resistant tuberculosis

Role: Project Manager


Foundation for Innovative New Diagnostics.    Denkinger (PI)    Tukvadze (site PI)                      2015-2017

“Accuracy and Feasibility of Xpert  (Xpert Ultra trial)”

Co-Investigator


NIH/NIAID  Vashakidze (PI)                                                                                                                  2015-2017

“Expanding global knowledge of tuberculosis by establishing the Georgia Tuberculosis Portal 2015-2017”

National Institute of Allergy and Infectious Diseases

Co-Investigator

 

NIH/NIAID K23 AI103044 Kempker (PI)                                                                                              2013-2018

Title: Intracavitary drug levels and drug resistance in tuberculosis.

The goals of this project are evaluate whether inadequate drug penetration into cavitary lesions leads to further acquired drug resistance among pulmonary multidrug resistant TB patients.

Role: Co-Investigator


Human Diagnostic Georgia Ltd. 

Evaluation of efficacy of Plasma Cluster technology for ensuring proper IC in TB Hospital                2015 - 2016

Role: Project Director

Training Program Co- Principal Investigator (Georgia);


Swiss National Fund, Switzerland-Georgia.                                                                                    2009-2012

Disability Status Assessment project

Project coordinator

   

2012-2014

Deputy Director

Inpatient Department , Tbilisi Central Hospital


2012-2013

Head of Program and Project Administration

clinic “Health Center


2010-2012

Deputy Director

Medical-diagnostic clinic “444”


2011-present

Medical doctor

Pathology / anatomy clinic “Geohospitals”


1998-2011

Patholog-anatomist

A. Aladashvili Clinic N1 of The Medical University 


2009-2010

Director

Vocational Training Center “Speqtri”


2007-2009

Head of Strategic Development and Quality Control Department

Department of Strategic Development and Quality Control, “Aversi” Clinic


2006-2008

Expert

International Consulting Group “Curatio”


2004-2005

Local manager

Educational project Socrates

EU-Tbilisi, Georgia


1988-1998

Medical Doctor

National Sepsis Center


1986-1988

Lieutenant

USSR Army Medical Corps
















 

Professional Membership


2014-present      Member of Phthisiologists and Pulmonologists Association of Georgia

2001 – 2004       Member of Board, Expert group on elaborating Georgian Law of High Education, Tbilisi,

2001 – Present   Member, Association of Atherosclerosis

2005                      Representative, Institutional evaluation project, Association of European Universities

2005 – Present   Board member, Association of Georgian Clinical Pathologists, Tbilisi, Georgia

2006 – Present   President, Association of Medical Education Professionals, Tbilisi, Georgia

2007 – Present   President, Association of Georgian Pathologists XXI, Tbilisi, Georgia

2002 – Present   Member, National Bioethics Council, Expert at Ministry of Labor, Health and Social Affairs,   

                           Tbilisi, Georgia

1999 – Present   Member, Association for Medical Education in Europe

1996 – 1997       Member of Interparliamentary Group for coordinating Healthcare Systems development in  

                           Caucasian Region, Azerbaijan, Armenia, Georgia

1994 – Present   Member, Association of Georgian Physicians, Tbilisi, Georgia




Complete list of published work in My Bibliography:

 

https://www.ncbi.nlm.nih.gov/myncbi/1NUtb9tjmcx5z/bibliography/public/

 

D.  Research Support 

 

Ongoing Research 

 

ERC-2019-AdG                                                                                                                      Tukvadze (PI)                                                             01/04/20–01/04/2025

Horizon 2020, the European Commission

Title: Linking Within-host and Between-Host Evolution in Multidrug-resistant Mycobacterium tuberculosis

The goal of this project is to explore the causes and consequences of within-host evolution in multidrug- resistant Mtb over time and across different body compartments, to look for potential trade-offs with between-host evolution during patient-to-patient transmission, and to define the role of suboptimal patient treatment and phenotypic drug tolerance on drug resistance evolution inside patients and across patient populations.